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BIO 3130

Embryology

I.      General Embryology

A.   Gamete Developme

1. Ova

a. Primordial

b. Oogonia

c. Primary Oocytes

d. Cyclic Development

i Primary Follicle

¨ Structures

ii Secondary Follicle

iii Secondary Oocyte

iv Ovulation

2. Sperm

a. Male Gonad

b. Puberty

c. Meiosis

d. Spermiogenesis

B. Ovulation

1. Endocrine Signal

2. Steps

a. Stigma Formation

b. Rupture

c. Transport

3. Corpus Luteum

a. Differentiation

b. Function

c. Fate

d. Maintenance

4. Fertilization

a. Site

b. Sperm Changes

c. ZP Penetration

d. Contact

e. Nuclei

C. Cleavage

1. Cleavage Stages

a. Blastomeres

b. Compaction

c. Morula

2. Blastocyst

a. Timing

b. Fluid

c. Zona Pellucida

3. Implantation

D. Bilaminar Germ Disc

1. Eighth Day

a. Trophoblast Differentiation

b. Embryoblast Differentiation

c. Amniotic Cavity

2. Ninth Day

a. Syncitiotrophoblast

b. Hypoblast

3. Eleventh-Twelfth Days

a. Epithelial Closure

b. Syncitiotrophoblast

c. Extraembryonic Mesoderm

d. Germ Disc

4. Thirteenth Day

a. Blood Flow

b. Primary Villi

c. Definitive Yolk Sac

d. Extraembryonic Coelom

e. Prechordal Plate

E. Trilaminar Germ Disc

1. Primitive Streak

a. Epiblast

b. Movement

c. Primitive Node

d. Primitive Pit

e. Cardiogenic Plate

2. Notochord

a. Pit

b. Fusion

c. Detachment

d. Function

3. Caudal Development

a. Cloacal Plate

b. Allantois

4. Placental Development

a. Villi

b. Cytotrophoblast: Shell

c. Cytotrophoblast: Core

d. Later Development

i Villi

ii Uterine Lumen

iii Amniochorionic Membrane

F. Embryonic Period: Organogenesis

1. Ectodermal Derivatives

a. Neural Plate

b. Fusion

c. Neural Crest

d. Placodes

2. Mesodermal Derivatives

a. Tubular Body

b. Somite Differentiation

c. Intermediate Mesoderm

d. Lateral Plates

e. Blood/Vessels

3. Endodermal Derivatives

a. Gut Tube

b. Prechordal Plate

c. Endoderm Fate

G. Fetal Period

1. Growth

a. Proportions

b. Maturation

c. Birth Date

d. Measurement

2. Diagnostic Techniques

a. Ultrasound

b. Amniocentesis

c. Chorionic Villus Sampling

H. Teratology

1. Numbers

2. Environmental Agents

a. Rubella Virus

b. Varicella

c. Hyperthermia

d. Radiation

e. Drugs

II. Special Embryology

A. Skeleton

1. Introduction

a. Contributing Tissues

b. Methods

2. Skull

a. Neurocranium

b. Viscerocranium

c. Abnormalities

3. Limbs

a. Limb Buds

b. 6th Week

c. 12th Week

d. Birth

e. Abnormalities

4. Vertebrae

a. Formation

b. Nerves/Muscles

c. Arteries

d. Abnormalities

B. Muscles

1. Origin

2. Myotome Divisions

a. Epimere

b. Hypomere

c. Ventral Hypomere Tip

3. Limbs

a. Origin

b. Upper Limb

c. Lower Limb

d. Innervation

4. Abnormalities

C. Head/Neck

1. Originating Tissues

2. Pharyngeal Arches

a. Introduction

b. 1st Arch

i Components

ii Muscles

iii Innervation

c. 2nd Arch

i Bones

ii Muscles

iii Innervation

d. 3rd Arch

i Bones

ii Muscles

iii Innervation

e. 4th & 6th Arches

i Cartilage

ii Muscles

iii Innervation

3. Pharyngeal Pouches

a. First

b. Second

c. Third

d. Fourth

e. Fifth

4. Pharyngeal Clefts

a. Ext. Auditory Meatus

b. Overgrowth

5. Arch Abnormalities

a. Treacher-Collins Syndrome

b. Pierre Robin Syndrome

c. DiGeorge Syndrome

6. Tongue

a. Origin

b. Growth

c. Innervation

7. Thyroid

a. Origin

b. Migration

c. Thyroglossal Cysts

8. Face

a. Originating Structures

b. Nasal Placodes

i Description

ii Development

iii Maxillary Prominences

iv Intermaxillary Segment

v Secondary Palate

vi Failures

9. Teeth

a. Initial Formation

b. Component Formation

c. Permanent Teeth

D. Central Nervous System

1. General Description

a. Originating Tissues

b. Dilations

c. Flexures

d. Further Divisions

i Prosencephalon

ii Rhombencephalon

¨ Metencephalon

¨ Myelencephalon

¨ Pontine Flexure

e. Cavities

2. Spinal Cord

a.    Neuroepithelium

b.    Neuroblasts

c.     Marginal Layer

d.    Plates

e.    Glial Cells

f.       Ependymal Cells

g.    Neural Crest

h.    Myelination

i.        Positioning

3. Brain

a. Myelencephalon

i Rotation

ii Basal Plates

iii Alar Plates

b. Metencephalon

c. Mesencephalon

i Ventral

ii Dorsal

d. Diencephalon

i Components

ii Roof Plate

iii Alar Plate

iv Hypophysis

e. Telencephalon

i Corpus Striatum

ii Choroid Plexus

iii Hippocampus

iv Divisions

f. Cranial Nerves

i Origin

ii Ganglia

g. Sympathetic N.S.

i Origin

ii Other Ganglia

iii Preganglionic Fibers

iv Postganglionic Fibers

h. Adrenal Glands

i Cortex

ii Medulla

i. Parasympathetic N.S.

i Preganglionic

ii Postganglionic

E. Digestive System

1. Introduction

a. Basic Components

b. Tissue Contributions

c. Mesenteries

i Dorsal

ii Ventral

2. Foregut

a. Esophagus

i Location

ii Abnormalities

b. Stomach

i Rotations

ii Mesenteries

¨ Dorsal

¨ Ventral

¨ Margins

iii Abnormalities

c. Duodenum

d. Liver

i Origin

ii Ducts

iii Sinusoids

iv Bare Area

v Hematopoiesis

e. Pancreas

i Initial Formation

ii Fusion

iii Ducts

iv Endocrine

v Abnormalities

3. Midgut

a. Initial Structure

b. Rotation

c. Physiologic Herniation

d. Mesenteries

4. Hindgut

a. Products

b. Cloaca

c. Anal Canal

d. Abnormalities

F. Cardiovascular System

1. Initial Development

a. First Sign

b. Second Event

2. Heart Tube

a. Folding

b. Connections

c. Cavity

d. Tissues

3. Cardiac Loop

a. Cause

b. Expansions/Constrictions

i. Atrium

ii. AV Canal

iii. Outflow Portions

4. Venous Changes

a. Parts

b. Changes

5. Septa

a. Atrial Differentiation

i 28th Day

ii 33rd Day

b. AV Canal

i Endocardial Cushions

ii Valves

c. Atrial/Valvular Defects

i Septum

¨ Ostium Secundum

¨ Common Atrium

¨ Oval Foramen

ii Canal

¨ Persistent AV Canal

¨ Tricuspid Atresia

d. Arterial/Ventricular Septum

i 5th Week

ii SL Valves

iii Defects

¨ VSD

¨ Tetralogy of Fallot

¨ PTA

¨ Transposition

¨ Stenosis

¨ Dextrocardia

e. Arterial Development

i Arches

ii Fate

BIO 3130
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September 6, 2006  (Audio  only)

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