BIO
4125 Bio of
Aging I. General Considerations of Aging A. Aging at the Population Level 1. Lifespan a. Survival Curves b. Potential c. Causes of Termination i. Trauma/ Accidents ii. Disease iii. Homeostatic Failure d. Long Livers 2. Man As A Special Case a. Correlates b. Brain Weight c. Another Exception 3. Technical Aspects of Aging Studies a. Types of Studies i. Cross-sectional ii. Longitudinal iii. Inherent Problems B. Cell/ Tissue Aging 1. Homeostasis and Age a. Homeostatic Mechanisms i. Components ii. Effectiveness iii. Aging Fault b. End-Point in Impairment 2. Aging and the Immune System a. General b. Specific Aspects c. Models i. Chronic Graft vs. Host ii. Athymic Animals d. Other Relationships e. Summary 3. Cellular Aging a. Complexity b. General Signs c. Models i. Serial Transplantation ii. In Vitro Culture 4. Aging Theories a. Programmed Cell Death b. Error Theory c. Redundancy Failure d. “Killer Hormone” e. Free Radicals II. General Anatomical Changes A. Conformation 1. Height a. Cross-Sectional b. Longitudinal Studies c. Location of Loss 2. Shoulder Width 3. Pelvic Diameter 4. Chest Circumference 5. Head Circumference 6. Nose, Ears 7. Weight B. Composition 1. Adiposity a. Methods of Measurement b. Results i. Dilution Method ii. Specific Gravity Method iii. Skin Fold Thickness Method 2. Body Water III. Tissues and Organ Systems A. General Supporting Tissues 1. Blood a. Cells b. Volumes c. WBCs d. Platelets e. Proteins f. Marrow 2. Connective Tissue a. Gels b. Fibers c. Hyaline Cartilage d. Effects of CT Changes e. Bone i. Osteoporosis ii. Gender Differences iii. Explanations 3. Muscle a. Cells b. Motor Neurons c. Energy Production d. Physiologic Characteristics e. Muscle Strength 4. Skin a. Epithelial Pegs b.
Glands c.
Melanophores d.
Dermis e. Fat f. Nails g. Hair 5. Teeth a. Loss b. Potential c. Component Changes d. Attachment e. Gingiva f. Alveolar Bone g. Epithelium B. Respiratory System 1. Exchange a. Surface Area b. Total Lung Capacity 2. Elasticity a. Wall Position b. Deflation i. Chest at rest ii. FRC c. Cause 3. Thoracic Compliance a. Chest Wall b. Result c. Diaphragm d. Timed Air Flow 4. Defense a. Cilia b. Macrophages 5. Closing Volume a. Meaning b. With Age c. Result C. Cardiovascular System 1. The Heart a. Weight b. Myocardium c. Pigment 2. Arteries a. Structure b. Compliance c. Results 3. Veins 4. Capillaries 5. Circulatory Functional Changes a. Cardiac Output b. Perfusion c. Pressure 6. Physical Activity and Aging a. Physical Work Capacity b. Factors c. Conditioning D. Nervous System 1. Anatomic Change a. Weight b. Cortical Area c. Gray/ White Matter d. Cell Loss 2. Changes Within Cells a. “Dying Back” b. In Cell Bodies i. Inclusions ii. Microtubules c. Neuritic Plaque d. Supporting Tissues i. Astrocytes ii. Choroid Plexus iii. Arterioles e. Peripheral Nerves 3. Blood Flow 4. Neurotransmitters a. DOPA b. Catecholamines c. Monoamine Oxidase d. Acetylcholine e. GABA 5. Reflexes 6. Reaction Times a. Meaning b. Change c. Location of Change 7. Senses a. Cutaneous b. Proprioception c. Vision i. Presbyopia ii. Lens iii. Pupil iv. Visual Field v. Chemistry vi. Aqueous Humor vii. Persistence d. Hearing e. Taste |
BIO
4125 Audio Blackboards Spring
08-09 Spring
07-08 |
